58 / Monday, March 26, 2012 / Rules and Regulations Date of issue: 03/21/2014 Revision date: 02/27/2018 Supersedes: 03/21/2014 Version: 1.1 02/27 A shorter version, the ToxFAQs , is also available., is also available. It is found in paint thinner, inks, glues, stain removers, and nail polish, substances often used as inhalants. The drug discrimination procedure in animals has been extensively utilized to model the abuse related, subjective effects of drugs in humans, but it has seldom been used to examine abused volatile inhalants like toluene. Author information: (1)Department of Neurology, University of California, Davis 95616. Para Toluene Sulphonic Acid 107. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. The effects of high-dose toluene on embryonic development in the rat. A solvent meant to increase octane ratings in gasoline and used to make benzene, toluene acts as a central nervous system depressant and neurotoxin when concentrated fumes are inhaled. Gospe SM Jr(1), Saeed DB, Zhou SS, Zeman FJ. What Is Toluene? In this study, prenatal Inhaling toluene leads to a feeling of euphoria and several reports have shown that children born to women who had abused toluene during pregnancy present a syndrome (toluene embryopathy or fetal solvent syndrome) that is characterized by CNS effects (e.g. Para-toluene … It exists as a liquid at room temperature. Toluene (C6H5CH3) - Toluene is an aromatic hydrocarbon with the chemical formula C6H5CH3. Physical and cognitive effects of huffing can last up to several hours, depending on the type of inhalant and concentration level of the inhalant. For more details on Toluene … The first report of the fetal solvent syndrome in 1979 ( 60 ) described facial dysmorphia, growth retardation, and microcephaly similar to the fetal alcohol syndrome ( 60, 61 ). Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. Toluene is known to cause congenital disabilities and the birth rate of children when used by pregnant women [6] . Reprod Toxicol. Rationale Toluene is a misused inhalant with hallucinogenic properties and complex effects. This Public Health Statement is the summary chapter from the Toxicological Profile for Toluene.It is one in a series of Public Health Statements about hazardous substances and their health effects. Of course, more toluene is long to eliminate, it is likely to have adverse effects. The knowledge base consists of proprietary authored content describing clinical level information about drugs such as side effects and drug interactions, as well as molecular level data such as chemical structures and what proteins a drug interacts with. Effects on the CNS have also been observed in studies of animals chronically exposed by inhalation. Dsstox_cid_6701 105. Tobacco consumption and people exposed to toluene, alcohol partly determines the Elimination of the toxic. Toluene, trichloroethylene, and perchloroethylene inhibit whole Toluene blocks N-methyl-d-aspartate (NMDA) receptors, releases dopamine (DA), and modifies several neurotransmitter levels; nonetheless, the mechanism by which it produces hallucinations is not well characterized. The EPA has recommended a drinking water guideline value of 1 mg/L for toluene … To experiment hepatotoxicity effects of noise and toluene, 100 dB white noise and 1000 ppm toluene vapors were generated during two consecutive weeks in healthy male New Zealand White rabbits. EPA closely monitors and sets limits on toluene emitted from industrial sources; this includes the level of contaminants in drinking water at which no adverse health effects are likely to occur. Toluene is sometimes used as a recreational inhalant ("glue sniffing"), likely on account of its euphoric and dissociative effects. The prevalence of toluene abuse in women of reproductive age is growing and little is known about toluenes effects on neonatal outcomes. 62.1). Toluene toxicity refers to the harmful effects caused by toluene on the body. In summary, a wide variety of voltage-gated and ligand-gated ion channels are affected Figure 1: Trends in drug prevalence and funding from depicts a Toluene, the main component of volatile glues, lacquer thinners and aerosol paints is the chemical responsible for most clinical toxicity. Toluene levels in brain and blood were linearly related to toluene levels in inhaled air after rats were exposed to 50, 100, 500, or 1000 ppm (189, 377, 1885, or 3770 mg/cu m) toluene for 3 hr. Pages liées Suivi des pages liées Téléverser un fichier Pages spéciales Lien permanent Informations sur la page Citer cette page Élément Wikidata Le toluène, également appelé méthylbenzène ou phénylméthane est un hydrocarbure aromatique sous la forme d'un liquide transparent, très répandu et utilisé comme produit de départ industriel ou comme solvant. Non-simultaneous exposure to noise and toluene increased liver enzymes and the serum levels of superoxide dismutase , malondialdehyde, and total antioxidant capacity, and also decreased serum … Previous drug discrimination studies have implicated GABA A and NMDA receptor mechanisms as underlying the discriminative stimulus effects of toluene (Bowen and Balster 1997, Bowen et al. View This Abstract Online Toluene abuse embryopathy: longitudinal neurodevelopmental effects of prenatal exposure to toluene in rats. long-term deleterious effects of drug use than use started at later ages [52,53]. 1987a, Rees et, 4-methylphenylsulfonic Acid 106. Aim of this study was to investigate liver metabolism of with regard to para toluene-sulfonamide (PTS), CYP isoforms, P-glycoprotein (P-gp), and drug interactions. Effects of Solvents on Voltage-Gated Channels Toluene affects voltage-gated calcium, potassium, and sodium channels with variable potency and efficacy (Fig. (1,2) (1,2) Chronic inhalation exposure of humans to toluene … 77, No. including toluene are discussed in more detail in another paper of this issue [8]. Workers using toluene-containing paints, varnishes, shellac, nail polish, glues and adhesives, rust preventives or printing inks may be exposed to toluene. health effects from diisocyanate (1) exposure, and to provide guidance to assist with medical diagnosis and management. Para-toluene-sulfonic Acid 103. The effects are either … Smoking a hookah (also known as Workers can be exposed to toluene by breathing it in, getting it on their skin, getting it splashed into their eyes, or swallowing it. 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