The major isoflavones in red clover are biochanin A, formononetin, daidzein, and genistein; total phytoestrogen content is approximately 0.17%.1, 2, 3, 4, Much of the interest in red clover originated from observations of positive health benefits derived from the use of soy products. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. The red clover is easily identified by its reddish-pink globe-like flower, hairy stems, and unique “V” mark coloring on the three-lobed leaves. Few adverse reactions have been reported in doses used in clinical trials. Benefits of Red Clover Extract. For general supplementation: Drugs.com suggests using a daily dose of 40 to 120 mg of isoflavones per day (from soy) or 40 to 80 mg per day of isoflavones (from red clover) for various conditions. Because red clover thins the blood, those with blood-clotting abnormalities should probably not take this supplement. No side effects were observed.52, The Society of Obstetricians and Gynaecologists of Canada revised clinical practice guidelines on managing menopause (2014) recommend that complementary and alternative medicine that has demonstrated efficacy for mild menopausal symptoms, including products containing isoflavones sourced from red clover, may be offered by health care providers (Level I-B).54 The Endocrine Society clinical practice guidelines for the treatment of symptoms of the menopause (2015) recommend counseling patients on the lack of consistent evidence for benefit of complementary medicine therapies, including red clover, as an alternative nonhormonal therapy for vasomotor symptoms (weak recommendation; low quality evidence).55, In ovariectomized rats, red clover restored the pain threshold to levels matching those of the animals in the control group (intake ovary).27, Secondary outcomes of some clinical trials have included effects on CNS symptoms in postmenopausal women. Red clover contains isoflavones, a type of phytoestrogen. Note, the safety of the use of isoflavones, taken as a supplement, cannot be guaranteed when taken for a duration of longer than six months. Here are a few of the most common uses. Red clover does not seem to reduce menopausal symptoms. Isoflavones in RC supplements are very potent, so much lower doses are needed than when consuming the whole herb. Isoflavones are phytoestrogens—compounds similar to the female hormone estrogen. Red Clover? Genistein content may negate the effects of tamoxifen and aromatase inhibitors such as letrozole.26, Red clover contains disputed amounts of coumarin derivatives (including coumarin, medicagol, and coumestrol); however, the risk of anticoagulant abnormalities is low.1, 3, 37, 38, 39 A case report of bleeding exists; however, the patient was taking a combination preparation that included dong quai and Siberian ginseng, as well as red clover.40, Contraindicated in patients with hormonal disorders or estrogen-dependent breast cancer (or risk of), and during pregnancy or lactation. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. The isoflavone can be extracted directly from the red clover flower and made into capsules, tablets, liquid extracts, or topical creams depending on your particular symptoms that you want to treat and preferences. The leaves are in groups of 3 ovate leaflets, often notched at the tip, with a characteristic lighter water mark on their upper surface.1, 2, 3, 4, Dried red clover flowers have been used in traditional medicine to treat a wide spectrum of ailments, including jaundice, cancer, mastitis, joint disorders, and respiratory conditions (eg, whooping cough, bronchial asthma), and as a sedative. Avoid use; red clover has estrogenic activity. Data sources include IBM Watson Micromedex (updated 7 Dec 2020), Cerner Multum™ (updated 4 Dec 2020), ASHP (updated 3 Dec 2020) and others. Red clover ointments have been used topically to accelerate wound healing and to treat psoriasis, eczema, and rashes. There is a lot of poor quality red clover on the market. Clinical evidence is presently lacking to support the efficacy of semipurified red clover isoflavone extracts for alleviation of climacteric vasomotor symptoms or reduction of low-density lipoprotein levels in the blood. It is naturalized in North America, where its nitrogen-fixing properties are used in pasture renovation. A volatile oil that includes methyl salicylate is distilled from the flowers.3 Isoflavones are often termed "phytoestrogens" because of their functional similarity to estrogens. The median lethal dose in mice is estimated to be approximately 4 g/kg intraperitoneally.3 As a flavor or seasoning, Trifolium species are GRAS classified under the Federal Food, Drug, and Cosmetic Act.3. Moderate interactions of red clover include: Red clover has no known mild interactions with other drugs. Mean vegetative somatic scores (eg, hot flushes, heart discomfort, sleeping disorders) were significant (P = 0.002). Decreases of 70% were found for depression and anxiety compared with baseline. The usual dose is 40 to 80 mg/day of standardized isoflavones, typically containing biochanin A, formononetin, genistein, and daidzein. 2 or 3 times daily. Red Clover Preparations and Dosage Red Clover can be ingested in a number of ways. The herb was first utilized in 1917 as a blood purifier and amplified in the 1930s as a supposed anti-tumor remedy, in which its beneficial effects are still in popular use today. Today, extracts from red clover are most often promoted for menopause symptoms, high cholesterol levels, or osteoporosis. Dense terminal heads with up to 125 fragrant flowers are borne at the end of the branched stems. This information should not be used to decide whether or not to take this product. Red clover is available in various forms, including powder form. What Are Side Effects Associated with Using Red Clover? Up to 85 milligrams of isoflavones once daily seems to be safe for … Two: This is often used for children that have a persistent, bad cough. Red clover dosage One capsule contains 400 mg of the herb. Check with your physician for additional information about side effects. The plant was thought to purify the blood by promoting urine and mucus production, improving circulation, and stimulating secretion of bile. However, there is no clinical evidence to support any of these uses or for use in menopause-related conditions. You should talk with your health care provider for complete information about the risks and benefits of using this product. Health and Safety Code 26569.22. The appropriate dose of red clover depends on several factors such as the user's age, health, and several other conditions. Topical use of red clover includes for cancer, skin sores, burns, sore eyes, and chronic skin diseases including eczema. Both soy and red clover are sources of isoflavones and have similar estrogenic activity shown in in vitro studies to be approximately 0.25% that of 17-beta-estradiol.5, The use of red clover as natural hormone replacement therapy has been proposed because of its estrogenic activity. Red clover (Trifolium pratense) is a flowering plant.Like chickpeas and beans, it’s a legume. An Introduction to Red Clover Dosage Red clover (Trifolium pratense) is an herbal supplement that is typically used for natural menopause relief.Unlike medications (for which the standard doses have been well established in carefully designed studies), there is less information available about the best dosage for herbal supplements, including red clover. Dosage Considerations – Should be Given as Follows: Side effects of bismuth subsalicylate include: This document does not contain all possible side effects and others may occur. This medication contains red clover. Eczema, psoriasis, and rashes all respond to its soothing and healing qualities. What Other Drugs Interact with This information does not endorse this product as safe, effective, or approved for treating any patient or health condition. Red Clover Uses. Next to red peppers, you can get the most vitamin C from ________________. Total scores improved 10.33 points with red clover compared to 3.57 with placebo (P = 0.0001). Several commercial preparations are available. Red Clover is mainly used for its blood cleansing abilities, making it great for addressing skin conditions. Select one or more newsletters to continue. The Cochrane meta-analysis21 further includes 4 trials in which a preparation containing high amounts of genistein (more than 30 mg/day) were used. Copyright © 2020 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. Red clover supplementation is not advised in children younger than 12 years.1, 9, 36. It is often used as a nourishing herbal infusion, using 1 ounce of dry herb infused in a quart of just-boiled water. No side effects were observed.52, Changes in sexual symptoms were not found to be significantly different between the red clover and placebo groups in 3 of 4 studies reviewed systematically; one study, however, reported significant decreases in dyspareunia and low libido with administration of red clover compared to placebo (P<0.05). Extracts standardized for isoflavone content have been used frequently in clinical trials.26 These tablets contain biochanin A, formononetin, genistein, and daidzein.7 A usual dosage is 40 to 80 mg/day of total isoflavones (1 to 2 tablets). The estrogenic effects of red clover are well documented and may have an effect on the fetus. What Are Warnings and Precautions for Red Clover? Historically, red clover was used for asthma, whooping cough, cancer, and gout. Red clover blossoms for sedation were formerly used at doses of 4 g, but are now used primarily as a source of isoflavones, plant substances that can have healing effects. This information is not specific medical advice and does not replace information you receive from your health care provider. Medieval Christians associated the three leaves as a resemblance to the Holy Trinity and sought to use it in many aspects of diet and additives. In contrast, a reverse effect was seen in women experiencing at least 3 hot flashes/day. See additional information. It has al… Red clover is an herbal supplement used orally for conditions such as menopausal symptoms and hot flashes, mastalgia, premenstrual syndrome, cancer prevention, indigestion, hypercholesterolemia, whooping cough, asthma, bronchitis, and sexually transmitted diseases. Keep in mind that natural products are not always necessarily safe and dosages can be important. Although, a mean difference of 0.89 (95% CI, 0.26 to 1.52) was found for reduction in hot flushes compared with placebo for 10 studies.23, For red clover given over 3 to 4 months, a mean difference in hot flush frequency of −1.34 (95% CI, −1.9 to 0.77) was reported, whereas over 12 months, a nonsignificant difference was reported (0.89 [95% CI, −0.07 to 1.85]).22, The 3 meta-analyses,21, 22, 23 as well as other systematic reviews,1, 24, 25, 26 concluded that there is no compelling evidence of red clover efficacy in managing the vasomotor symptoms of menopause. If you feel that you are having any other health problems or are taking other medications, you should consult with your doctor before you take red clover. With the exception of vaginal dryness, no significant improvement was seen in urogenital subcategory scores; however, mean vegetative somatic scores (eg, hot flushes, heart discomfort, sleeping disorders) and differences in mean psychological scores (eg, anxiety, irritability, physical and mental exhaustion) were significant (P = 0.002, P = 0.0001, respectively). At this time there is not enough scientific information to determine an appropriate range of doses for red clover. Our Red Clover contains only the full Clover Blossoms and their accompanying leaves. Red clover has no known serious interactions with other drugs. The availability of clinical trial data and systematic reviews of red clover in menopause-related osteoporosis makes animal data less relevant. Red clover supplementation is not advised in children younger than 12 years. Three: Blood flow seems to be enhanced by this herb since it can help prevent blood clots and thins the blood. Extracts standardized for isoflavone content have been used frequently in clinical trials.26 These tablets contain biochanin A, formononetin, genistein, and daidzein.7 A usual dosage is 40 to 80 mg/day of total isoflavones (1 to 2 tablets). Additionally, significant reduction in vaginal dryness was reported with red clover (41% fewer symptomatic patients) compared to placebo (5% fewer symptomatic patients) in the one study that assessed this outcome (P<0.05).53. The availability of clinical trial data and meta-analyses of red clover in menopause makes animal data less relevant. Note, however, that research hasn't shown that the herb is conclusively effective for these or any other health concerns. With the exception of certain products that are generally recognized as safe in normal quantities, including use of folic acid and prenatal vitamins during pregnancy, this product has not been sufficiently studied to determine whether it is safe to use during pregnancy or nursing or by persons younger than 2 years of age. The current daily dose of isoflavones is 80 mg, as it is recommended to split that into 2 times, in the morning and in the evening. More studies are needed. See additional information. Several meta-analyses evaluating the efficacy of red clover and other phytoestrogens in reducing hot flushes have been published. Below are some suggestions. The use of red clover as an herbal remedy goes back centuries, and the plant enjoys a history of both topical and internal applications. However, the reviewers note the need for more evidence of safety at doses greater than 100 mg/day of isoflavones.46 Another systematic review and meta-analysis of 8 clinical trials found no effect of isoflavones on breast density in postmenopausal women, but some evidence of increased density in premenopausal women (mean difference, 1.83% [95% CI, 0.25% to 3.4%]).47 The reviews include a study that found mammographic breast density to be unaffected by 40 mg daily of red clover isoflavones for up to 3 years in women who had at least 1 first-degree relative with breast cancer (N = 401).22 No change in endometrial thickness or follicle-stimulating hormone levels has been reported.18, 48, 49 A study not included in the reviews, reported that use of red clover among 1,183 breast cancer survivors resulted in fewer reports of weight gain, night sweats, or difficulty in concentration.50 None of the botanical products used by these women were associated with health-related quality of life measures, fatigue, or hormonally related symptoms. 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