It treats the surfaces of the metal making them less susceptible to corrosion. One such patient was an 8-month-old who suffered a heart attack after four doses of topical medication to treat a burn. We sell to Everyone. Propylene glycol is a small organic alcohol commonly used as a skin … Propene is converted to, , a volatile compound used frequently in the creation process of polyurethane plastics (and to create propylene glycol). Acts as a coupling cosolvent in water-reducible aerosol paint formulations, and effective coalescent in water-borne latex coatings. (, Before the completed growth of these enzyme pathways, parents should avoid allowing their children to ingest or be exposed to many chemicals that are potentially harmful, and pregnant mothers should do the same. Free Delivery. And I’m not the only one. She was given Lorazepam for 18 days to treat her severe respiratory distress, at which time she developed, , a condition marked by lowering the body’s pH level to a dangerous extreme. While some research states that neonates (preterm infants) have been found to have no adverse side effects from propylene glycol, it’s also true that infants cannot break down this compound as quickly as an adult can. Registration dossier . The ADI for propylene glycol is 25 mg/kg body weight/day. Propylene glycol USP/EP (pharmaceutical grade), with its inherent property of attracting water , helps keep animal feed moist, fresh and chewy - … your liver from damage done by the common headache medication, Prospective mothers are usually very cautious during and after. When given Lorazepam for an extended period of time in large doses, clinicians have discovered possible kidney issues in the form of increased creatinine levels in the blood. “This fact is not always apparent, especially to those outside the field of veterinary medicine.”, Need a refresher? instead of margarine for an immediate health booster to your cooking. It’s also present in antifreeze, paint, and e-cigarettes. It is an additive in human and … efficiently and should avoid exposure when possible. Brutlag says propylene glycol is commonly used to absorb extra water and maintain moisture in certain medicines, cosmetics and dog and human food products and is categorized by the U.S. Food and Drug Administration (FDA) as a "GRAS" (generally recognized as safe) substance for this use. Propylene glycol alginate (PGA) is an ester of alginic acid, derived from brown seaweed, and food additive used to stabilize, thicken, and emulsify [ 1 ]. Propylene glycol has been designated by the FDA as “generally recognized as safe,” or GRAS, for consumption; however, according to the Federal Agency for Toxic Substances and Disease Registry, "We have little information about what happens to propylene glycol in the air." > Specifically, the FDA says propylene glycol is GRAS for use in animal feeds as a general-purpose food additive when used in accordance with good manufacturing and feeding practices. Containing two alcohol groups, it is classed as a diol. Getty Images> Ice cream (Cold Stone Creamery, Blue Bunny Sweet Freedom Vanilla Ice Cream Cones, Edy's Slow Churned Peppermint Wonderland), > Flavored ice tea (Dunkin' Donuts flavored iced tea, Nestea Liquid Water Enhancers), > Packaged frosting (some Betty Crocker varieties), > Boxed cake mix (Betty Crocker and Duncan Hines), > Skin care products, hair care products and cosmetics, The Association of American Feed Control Officials, Blue Bunny Sweet Freedom Vanilla Ice Cream Cones. Several common foods containing this compound include: Most natural alternatives to propylene glycol involve choosing foods and cosmetics free of the substance. However, critically ill adults may be an exception to this rule. "Propylene glycol functions as a humectant food additive and preservative. Propene is converted to propylene oxide, a volatile compound used frequently in the creation process of polyurethane plastics (and to create propylene glycol). There are a great deal of “clean” household products available, both commercially or of the DIY variety, and they will help you to greatly reduce your chemical exposure. > Ethanol or 4-MP (fomepizole) are the only two antidotes for ethylene glycol or antifreeze poisoning. It’s certainly less dangerous than, for example, ethylene glycol, a toxic chemical compound still used in many types of antifreeze and other household products. Here are some facts about Propylene Glycol (PG): It is a SYNTHETIC liquid which is water-soluble; It is obtained from the hydration of propylene oxide, which is derived from petroleum products. Each hydroxyl group is separately attache… That doesn’t necessarily quell concerns, however. As it’s found in food as an additive (in the U.S., at least), the U.S. Department of Agriculture refers to it via the E-number E1520. "Beneful consumers love the variety of ingredients, which includes some kibble that is crunchy and some that is soft and moist. It’s unlikely that you will experience any major adverse reactions to propylene glycol through normal exposure from food or cosmetics. A horse was also reported to suffer a myocardial edema after a mistaken oral dosage of a very large amount of propylene glycol. (14). (3) It (correctly) designates the known issues with propylene glycol to be in the “allergies and immunotoxicity” category, with no hazard related to cancer or reproductive processes. So, although propylene glycol may not be as terrifying as some people claim, it does have enough red flags to cause me to recommend avoiding it. Photo courtesy of Nestlé Purina> According to Wendy Vlieks, director of corporate public relations for Nestlé Purina PetCare, USP propylene glycol concentrations in the Beneful diet are less than 2 percent. ), The first three of these points seem to be encouraging. 1 Ever heard of propylene glycol? However, critically ill adults may be an exception to this rule. It is not used in ProPlan, Purina One, Beyond, Alpo and Chef Michael's dry dog food formulas. The Food and Drug Administration (FDA) has classified propylene glycol as an additive that is “generally recognized as safe” for use in food. This article is based on scientific evidence, written by experts and fact checked by our trained editorial staff. Anyone wishing to submit new scientific information on the use of this additive or to submit any inquiries may do so in writing, by regular mail or electronically. And I’m not the only one. Propylene glycol (1, 2- propanediol) is an organic compound (a diol alcohol) and is a tasteless, odorless and colorless clear oily liquid. Ethylene glycol and propylene glycol are organic compounds with alcohol functional groups. It’s completely soluble in water, and one major purpose it serves is as a “vehicle” for topical products, such as lotions. Stage 1: This occurs within 30 minutes to 12 hours and looks similar to alcohol poisoning. “Propylene glycol is a synthetic liquid substance that absorbs water. Weil CS, Woodside MD, Smyth HF Jr, Carpenter CP. Generally, creatinine (a product of muscle breakdown and growth) remains in consistent levels in the bloodstream. > Brutlag says that, historically, some semi-moist cat foods contained 5 to 10 percent propylene glycol, which caused Heinz body formation in cats. Many people are extremely concerned by the presence of an ingredient in antifreeze (one that’s used to deice airplanes, no less) in their food, which has sparked uproar in recent years, especially when three European countries pulled a popular alcoholic drink off the shelves for an illegal level of propylene glycol. One interesting case study followed a 24-year-old woman diagnosed with pneumonia. > Purina's recommended daily feeding for Beneful Original dry dog food for adult dogs is as follows: • 13 to 20 lbs., feed 1-1/4 to 1-2/3 cups, • 21 to 35 lbs., feed 1-2/3 to 2-1/2 cups, • 36 to 50 lbs., feed 2-1/2 to 3 1/4 cups. This food additive belongs to a group of chemicals called alcohols. All rights reserved. Propylene glycol (PG) is used as a solvent of various food additives and is frequently added to noodles and some kinds of foods made from wheat flour to increase water coating ability. Order online or call 800-658-7716. As a food additive, propylene glycol is recognized as safe by the U.S. Food and Drug Administration (FDA). The minimum lethal dose of ethylene glycol is 4-6 ml/kg body weight in dogs.” According to Pet Poison Helpline, common signs of ethylene glycol poisoning occur in stages. Propylene glycol is a synthetic food additive that belongs to the same chemical group as alcohol. (9). The information in our articles is NOT intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. "Results of feeding propylene glycol in the diet to dogs for two years," Food Cosmet Toxicol 1971 Aug;9(4):479-90. Many substances can be potentially toxic in massive doses, and it’s impossible to guarantee these chemicals do not build up in dangerous levels, especially in some cases. However, the organization states in the report that, “No studies were located regarding respiratory, cardiovascular, gastrointestinal, musculoskeletal, hepatic, renal, endocrine, dermal, ocular, or body weight effects in humans, or musculoskeletal, dermal, or ocular effects in animals after oral exposure to propylene glycol.” Similar statements were made about skin exposure and inhalation exposure. Propylene glycol (IUPAC name: propane-1,2-diol) is a viscous, colorless liquid, which is nearly odorless but possesses a faintly sweet taste. ... Lubricants and lubricant additives. A 2007 study from the University of Connecticut assessed the treatment of propylene glycol toxicity and also noted it can be dangerous for those with liver problems. > Nestlé Purina pet foods, including Beneful, are "only released after we confirm all of the ingredients are included at the right levels. (11), The one area in which the CDC’s toxicity profile negatively assessed propylene glycol was in the area of neurological symptoms. Severe lethargy, coma, depression, vomiting, seizures, drooling and inappetance may be seen. Pros, Cons + How to Use, Top 7 Foods that Boost Testosterone (Plus Testosterone-Killing Foods), What Is Allspice? Propylene glycol is only an ingredient in varieties of Dog Chow that are softer, like for seniors, or have a mix of moist and crunchy kibble," Vlieks says. Our team includes licensed nutritionists and dietitians, certified health education specialists, as well as certified strength and conditioning specialists, personal trainers and corrective exercise specialists. When administered large doses of Lorazepam, adults with or without kidney issues have experienced an abnormal buildup of propylene glycol. Prospective mothers are usually very cautious during and after pregnancy to ensure their children’s health. Sick of hearing about propylene glycol? It is not used in ProPlan, Purina One, Beyond, Alpo and Chef Michael's dry dog food formulas. Propylene glycol n-propyl ether. > Although both propylene glycol and ethylene glycol are chemically classified as glycols and both are metabolized, as a first step, by the same enzyme in the liver (alcohol dehydrogenase), ethylene glycol has a much high toxicity. The oral median lethal dose (LD50) of propylene glycol in dogs has been reported to be ~9 ml/kg body weight. A great number of cosmetics include propylene glycol, but in the U.S., cosmetics aren’t very well-regulated. Stage 2: This occurs 12 to 24 hours after a dog or cat has gotten into antifreeze, and signs of “alcohol” poisoning appear to resolve while underlying severe internal damage is still occurring. (1) Another name for it is “propane-1,2-diol,” which is sometimes used when listing it as a compound on ingredient labels. What is Propylene Glycol? This drug is often administered to patients with extensive burns as sedation during the healing process or to psychiatric patients. It is a solvent for food colors and flavors, and in the paint and plastics industries. Can also be used in radiate tube heating systems, most solar heating systems, and geothermal loops. It is used as a humectant (to keep food from drying out) and solvent in food products, including baked goods, cereal, candy, and dehydrated foods. (10a, 10b) This is due to the enzyme pathways that are still in development at the time of birth — depending on whom you ask, the period of development can last anywhere from six months to four years. Yet this chemical compound is mixed into thousands of grocery items as a food additive, as well as certain medicines and cosmetics, — even the food our pets eat. And, unlike ethylene glycol, it won't hurt paint, clothing or your skin. However, what, Propylene glycol (often referred to as PG) is the third “product” in a chemical process beginning with, , a byproduct of fossil fuel (oil refining and natural gas processing) and also found in nature as a byproduct of fermentation. Brown seaweeds have been used as a food for centuries but it is only since 1929 that alginates have been manufactured on an industrial scale [ 2 ]. of body weight beyond 100 lbs. Propylene glycol is found in many industrial and commercial products, including antifreeze, liquid laundry detergent solvents and paint. Propylene glycol (1, 2-propanediol) is an organic compound (a diol alcohol) and is a tasteless, odorless and colorless clear oily liquid. However, when considered the uses, both are used for somewhat same purposes. Propene oxide then goes through a hydrolyzation process to get propene glycol. You can replace many items containing this chemical in your home with DIY or organic versions. > “Propylene glycol is one of the least toxic glycols," says veterinary toxicologist Ahna Brutlag, DVM, MS, DABT, DABVT, associate director of veterinary services for Pet Poison Helpline. A 2007 study from the University of Connecticut assessed the treatment of propylene glycol toxicity and also noted it can be dangerous for those with liver problems. Propylene glycol is found in thousands of cosmetic products as well as a large number of processed foods products. (, One interesting case study followed a 24-year-old woman diagnosed with pneumonia. Nobody likes to hear that an ingredient in antifreeze — propylene glycol — is also found in food. Signs include ataxia (walking "drunk"), drooling/hypersalivating, vomiting, seizuring, vomiting and excessive thirst and urination. Excess creatinine is a sign that the kidney is unable to process compounds at a normal rate. On its own, propylene glycol is a clear, odorless liquid that is a bit more syrupy than water. The concern arises when propylene glycol is heated up and inhaled. Premixed ready-to-use formulation. It rates, a “3” on its health concerns scale, meaning the hazard it presents is moderately low. The Food and Drug Administration (FDA) has classified propylene glycol as an additive that is “generally recognized as safe” for use in food. Propylene glycol (often referred to as PG) is the third “product” in a chemical process beginning with propene, a byproduct of fossil fuel (oil refining and natural gas processing) and also found in nature as a byproduct of fermentation. Again, this information reflects available research. > As with any chemical, it's the dose that makes the poison, Brutlag says. Propylene glycol is used in many IV medications, including Lorazepam, an anxiety-reducing and seizure treatment medication. What if a dog does ingest a toxic amount of propylene glycol? There are conflicting reports regarding the impact of inhaled propylene glycol. (, ) (Nearly all the research used to support the “safety” of this chemical was done on rats, horses or monkeys — and a great deal of the points were made based on a study done on monkeys more than 60 years ago. Stage 3: In cats, this stage occurs 12 to 24 hours after getting into antifreeze. In food, it’s used as an anti-caking agent, antioxidant, emulsifier, processing aid, and thickener, among other uses. "The other brands just include hard crunchy kibble.". It is a colorless, nearly odorless liquid. In general, glycols are non-irritating and have very low volatility. (. (6). Propylene is one of … The EU limit is 5.3 percent. Propylene oxide is considered a “probable carcinogen.” Finally, through a hydrolyzation process (separating molecules by the addition of water), you get propylene glycol. Like ethylene glycol, propylene glycol may also be used as antifreeze and can be found in high concentrations in RV and “pet-friendly” antifreezes. Before the completed growth of these enzyme pathways, parents should avoid allowing their children to ingest or be exposed to many chemicals that are potentially harmful, and pregnant mothers should do the same. Propylene glycol as both a direct and indirect food ingredient additive is “Generally Recognized As Safe” (GRAS) by the US Food and Drug Administration (FDA). Propylene glycol is used in drugs and foods that veterinarians routinely give dogs for therapeutic intervention,” she says. But what concerns me most is what is not found there — any sort of extensive human-based research on its safety. In other words, we use propylene glycol to help keep the semi-moist kibbles soft and moist," Vlieks says. This common food additive may be the cause of your mystery allergies. Propylene glycol is considered “generally” safe by the FDA. When taken orally and tested by patch test to find the amount of the chemical still in their system, a number of people were found to have varying degrees of neurological issues, including stupor, convulsions and other unspecified “severe mental symptoms.”, In a cat-based study, cats receiving the high dose developed “decreased activity, mental depression, and slight to moderate ataxia.”. If exposed to the eyes and facial area, propylene glycol can also be an irritant and cause mild conjunctivitis. and symptoms have been commonly associated with propylene glycol exposure, mostly in part due to a few case studies that have caused alarming concern. Their molecular formulas are different; thus they have some different physical properties. After discontinuing the drug that poisoned her body, her condition stabilized for a period of time, but she later died after her condition deteriorated again. As it’s a fairly common ingredient in smoke machines (for theater productions) and other inhalable substances, this is an important distinction to make. Usually, this happens in people who are allergic to the chemical and subsides after a short period of time after the body has had time to break down the compound. “Dogs are much less at risk than cats from many chemicals, propylene glycol included,” Brutlag says. Odds are you wouldn’t eat something that includes the same ingredient – propylene glycol – found in antifreeze, paint, and plastics. Note that the numbers in parentheses (1, 2, etc.) Because household cleaners often contain propylene glycol, I encourage you to try my. There is no hard and fast answer to that question, however — according to a fair amount of research, the effects of propylene glycol are rarely negative and generally associated with extremely large, intravenous dosage levels. ), 11 Best Sugar Substitutes (the Healthiest Natural Sweeteners), Quercetin: 8 Proven Benefits of This Antioxidant (#1 Is Incredible), Chia Seeds Benefits: The Omega-3, Protein-Packed Superfood, 9 Proven Black Seed Oil Benefits that Boost Your Health, Top 15 Potassium-Rich Foods to Start Eating Today, Rice Cakes: Are They Healthy? Propylene glycol is a synthetic liquid substance that absorbs water. A great number of cosmetics include propylene glycol, but in the U.S., Frozen desserts (ice cream, frozen yogurt, etc. It’s important here to note that the humans in the noted studies above had been exposed to orally administered medication containing propylene glycol and were most likely allergic to it. , contributing to taste and “smoothness” of the smoke. Lotions and baby wipes also make the list of products that commonly contain this chemical. Although this chemical compound is not generally found in nature, it seems to be potentially safe. During this stage, severe kidney failure is developing secondary to calcium crystals forming in the kidneys. As electronic cigarettes also contain large amounts of propylene glycol, e-cigarette users may also try the alternative of. Excess creatinine is a sign that the kidney is unable to process compounds at a normal rate. A synthetic liquid substance that absorbs water, propylene glycol classified by the chemical formula C3H8O2. The term glycol is used when there are two hydroxyl groups present in neighboring carbon atoms. e-cigarettes, the organic alternative — though I recommend quitting smoking entirely, of course. Propylene glycol is practically odorless and tasteless. > Vlieks says the "no observed adverse effect level" (NOAEL) for propylene glycol is 8 percent of diet, meaning dogs fed at 8 percent propylene glycol in their diet for two years had no adverse effects.1, > Propylene glycol is found in Nestlé Purina's Beneful and some Dog Chow brands of dry dog food. People who already operate with poor kidney function are unlikely to be able to process propylene glycol efficiently and should avoid exposure when possible. The Food and Drug Administration (FDA), in a toxicological profile, has deemed propylene glycol as “generally recognized as safe.”, In the Centers for Disease Control and Prevention’s exhaustive report of the effects and possible toxicity of propylene glycol, no major health concerns were found. It is made from propene (a byproduct of fossil fuel) through a chemical process. Separately attache… “ propylene glycol, I encourage you to try my Liver. Carpenter CP conflicting reports regarding the impact of inhaled propylene glycol, e-cigarette users also... Is classed as a skin … the ADI for propylene glycol, e-cigarette users may try... With two carbon atoms and geothermal loops cushions, paints and the.! Desserts ( ice cream, Frozen yogurt, etc. less susceptible to corrosion pet food,,. From propene ( a byproduct of fossil fuel ) through a chemical process place you will find it classed. This drug is often administered to patients with extensive burns as sedation during the healing process or to patients! Unlike ethylene glycol is a colorless, slightly syrupy liquid that is crunchy and some that is soft and,. Protection additives formulated for heating and cooling systems range of solvents, including redness. Not used in many cosmetic and personal care products high-purity triple protection formulated. Bay Leaf Benefits for Digestion, Wounds and Diabetics you probably won ’ t quell. 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Research surrounding this substance is considered “ non-toxic antifreeze. ” administered large doses of medication... Usually very cautious during and after other household products coma, depression, vomiting, seizures, drooling inappetance! Calcium crystals forming in the same chemical group as alcohol is Allspice other brands just hard... Real truth about propylene glycol includes mild skin irritation, including causing redness foods as you.! Antifreeze. ” t have “ propolyne glycol-free ” options unless they ’ re homemade an 8-month-old suffered! This compound include: most natural alternatives to propylene glycol may also the! Thousands of cosmetic products as well as a base for deicing solutions through normal exposure from food or cosmetics have... Dogs has been much frustration and confusion about the safety of propylene glycol in your home with DIY or versions... Propensity to absorb whatever it comes into contact with thousands of cosmetic products as well a! Treat a burn kidney failure, the horse mentioned above who suffered edema. Love the variety of mild to moderate side effects in humans, this stage occurs 36 to hours! Is not generally found in nature, it seems to be not thorough...